Topographic map refinement and synaptic strengthening of a sound localization circuit require spontaneous peripheral activity
نویسندگان
چکیده
منابع مشابه
Synaptic refinement of an inhibitory topographic map in the auditory brainstem requires functional Cav1.3 calcium channels.
Synaptic refinement via the elimination of inappropriate synapses and strengthening of appropriate ones is crucially important for the establishment of specific, topographic neural circuits. The mechanisms driving these processes are poorly understood, particularly concerning inhibitory projections. Here, we address the refinement of an inhibitory topographic projection in the auditory brainste...
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A model of topographic map development is presented which combines both weight plasticity and the formation and elimination of synapses as well as both activity-dependent and -independent processes. We statistically address the question of whether an activity-dependent process can refine a mapping created by an activity-independent process. A new method of evaluating the quality of topographic ...
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Nucleus laminaris (NL) neurons encode interaural time difference (ITD), the cue used to localize low-frequency sounds. A physiologically based model of NL input suggests that ITD information is contained in narrow frequency bands around harmonics of the sound frequency. This suggested a theory, which predicts that, for each tone frequency, there is an optimal time course for synaptic inputs to ...
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OF THE TALK The term neuromorphic was coined by Carver Mead, in the late 1980s to describe Very Large Scale Integration (VLSI) systems containing electronic analog circuits that mimic neuro-biological architectures present in the nervous system. I will talk about topographic, largely neuronal maps in biology, how I've modelled their development, and how I've implemented this model in neurmorphi...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2019
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp277757